Ohio State Navbar

Patient Care

Clinical Trials


             At the James Cancer Hospital we are all committed to excellent patient care. For us, excellent patient care means not only providing state-of-art radiation therapy using all of the latest techniques and treatment modalities, but also providing clinical trial opportunities for as many patients as possible. 

Clinical Trials are the major way that we as cancer researchers assess new treatments and bring innovative drugs, techniques, or technologies into the clinic. We all want a world were cancer doesn't shorten peoples lives or take away quality of life- and the way to get there is by rigorously studying new treatments in clinical trials. Therefore, we will discuss with you the available clinical trial options durin ghte consultation and we ask that you strongly consider participating if you feel the clinical trial is right for you. 

Radiation Oncology Clinical Trials at the James Cancer Hospital

Breast Cancer

  • NSABP B39/RTOG 0413: Comparing the effectiveness and safety of three types of partial-breast irradiation and comparing them to whole-breast irradiation (Source: ASTRO)
     
  • RTOG 1005: Determining whether an accelerated course of hypofractionated WBI including a concomitant boost to the tumor bed in 15 fractions following lumpectomy will prove to be non-inferior in local control to a regimen of standard WBI with a sequential boost following lumpectomy for early-stage breast cancer patients. (Source: RTOG)

Central Nervous System Cancers

  • RTOG:0834 : Phase III Trial on Concurrent and Adjuvant Temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma The CATNON Intergroup trial
     
  • RTOG: 0837 Radomized, Phase II, Double-blind, Placebo-controlled Trial of Conventional Chemoradiation and Adjuvant Temozolomide Plus Cediranib versus Conventional Chemoradiation and Adjuvant Temozolomide Plus Placebo in Patients with Newly Diagnosed Glioblastoma

Gastrointestinal Cancers

  • RTOG 1010- Phase III trial evaluating the addition of trastuzumab to trimodality treatment of HER2-overexpressing Esophageal Adenocarcinoma
  • NCCTG-N1048 (PROSPECT):  A Phase II/III trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision.

  • OSU-12054:  A Phase I Trial of MEK Inhibitor GSK1120212 in Combination with Neoadjuvant 5-Fluorouracil Chemoradiation in the Treatment of KRAS, BRAF, and NRAS-Mutant Rectal Cancers

  • RTOG 1112:   Randomized Phase III Study of Sorafenib versus Stereotactic Body Radiation Therapy followed by Sorafenib in Hepatocellular Carcinoma

  • OSU 15032: A Pilot Trial of Stereotactic Body Radiation Therapy (SBRT) to Induce Tumor Hyperemia in Combination with Transarterial Chemoembolization (TACE) for Unresectable Hepatocellular Carcinoma

  • NRG-GI-001:  RANDOMIZED PHASE III STUDY OF FOCAL RADIATION THERAPY FOR UNRESECTABLE, LOCALIZED INTRAHEPATIC CHOLANGIOCARCINOMA

  • OSU 13098:  A Phase III Study of Chemotherapy With or Without Algenpantucel-L (HyperAcute®-Pancreas) Immunotherapy in Subjects with Borderline Resectable or Locally Advanced Unresectable Pancreatic Cancer

  • OSU-14117: NEOADJUVANT GMCITM PLUS MODIFIED FOLFIRINOX AND CHEMORADIATION FOR ADVANCED NON-METASTATIC PANCREATIC ADENOCARCINOMA

Genitourinary Cancers

Coming soon!
 

Gynecological Cancers

  • GOG- 263: Randomized Phase III Clinical Trial of Adjuvant Radiation Vs. Chemoradation in intermediate risk, Stage I/II Cervical Cancer treated with Inital Radical Hysterectomy and Pelvic Lymphadenectomy.
     
  • GOG-0265: A Phase II evaluation of ADXS11-001 (NSC 752718, BB-IND #13,712) in the treatment of persistant or recurrent Squamous or Non-Squamous Cell Carcinoma of the cervix. 
     
  • GOG-0274: A Phase III trial of adjuvant chemotherapy following chemoradiation as primary treatment for locally advanced cervical cancer compared to chemoradiation alone: THE OUTBACK TRIAL
     
  • OSU-13151: Randomized Phase II study of intravenous 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine® NSC #663249) Cisplatin-Radiochemotherapy vs. Intravenous Cisplatin-Radiochemotherapy in women diagnosed with stage IB-IVA Cervical Cancer and Stage II -IVA Vaginal Cancer. 
     
  • OSU 10014 Effects of Robotic Surgery on radiation therapy planning and delivery of Gynecologic malignancies-A retrospective Review
     
  • RTOG-1203: A Randomized Phase III study of Standard vs. IMRT Pelvic radiation for post-operative treatment of Endometrial and Cervical Cancer (TIME-C)
     
  • RTOG-0724 Phase III Randomized study of concurrent chemotherapy and pelvic radiation therapy with or without adjuvant chemotherapy in high-risk patients with early-stage cervical carcinoma following radical hysterectom

Head and Neck Cancer

  • RTOG-1008 - A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
     
  • RTOG-0920 - A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer
     
  • RTOG-1016 - PHASE III Trial of Radiotherapy Plus Cetuximab versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer
     
  • OSU-09074 - Phase I/II study of dasatinib, cetuximab and radiation with or without cisplatin in locally advanced squamous cell carcinoma of head and neck (HNSCC)
     
  • OSU-09120 - Phase I Trial of Vorinostat in the Treatment of Advanced Staged Oropharyngeal Squamous Cell Carcinoma

Leukemia and Lymphoma

  • NCT-02122081:  Clinical Trial aims to assess feasibility and tolerability of organ-sparing marrow-targeted irradiation (OSMI) to condition patients with High-Risk Hematology Malignancies prior to Allogeneic Hematopoietic Stem Cell Transplantation. 

Melanoma and Skin cancers

Phase I Study of Ipilimumab Combined with Whole Brain Radiation Therapy or Radiosurgery for melanoma Patients with Brain Metastases- In Development

A pilot study using stereotactic ablative radiation therapy and ipilimumab in patients with oligometastatic melanoma- In Development

Sarcoma

Coming soon!

Thoracic Cancers

  • OSU 14091: A Phase II trial combining Hypofractionated radiation boost with conventionally fractionated chemoradiation in locally advanced NSCLC not suitable for surgery. 

  • OSU 14034: A Phase 1 study of Trametinib in combination with chemoradiation for KRAS Mutant NSCLC

  • NRG LU001: Randomized Phase II trial of concurrent chemoradiotherapy +/- Metformin HCL in locally advanced NSCLC

  • RTOG 1306: Randomized Phase II study of individual combined Modality Therapy for Stage III NSCLC

  • NRG-BR01: A Phase I study of Sterotactic Body Radiotherapy (SBRT) for the treatment of multiple metastases. 

  • OSU 08111: MR-Predictive-Assay in pre-operative lung cancer therapy: Response/Resectability

  • Pulmonary Rehabilitation in locally advanced NSCLC

  • CALGB 30610: Phase III comparison of the thoracic radiotherapy regimens in patients with limited Small Cell Cancer also receiving Cisplatin and Etoposide. 

  • OSU 12223: A Pilot study of Pleural Photodynamic Therapy for patients with Pleural Malignancy 

  • OSU 08111: An MR-Predictive-Assay in Pre-Operative Lung Cancer Therapy: Response/Resectability

  • OSU 13197: A Phase 1 study of Trametinib in combination with radiation therapy for Brain Metastases from KRAS-, BRAF-, NRAS- or HRAS- Mutant Malignancies.